Associate Professor Jiawen Li pawg ntawm University of Science thiab Technology ntawm Tuam Tshoj (USTC) tau thov kom muajfemtosecond laserdynamic holographic ua txoj kev tsim nyog rau kev tsim kho ntawm peb-dimensional capillary scaffolds, uas yuav siv tau los tsim peb-dimensional capillary tes hauj lwm. Cov kev tshawb fawb muaj feem xyuam tau luam tawm raws li ib daim ntawv npog hauv Cov Khoom Siv Ua Haujlwm Zoo Tshaj Plaws, thiab cov cuab yeej muaj feem cuam tshuam tau raug tso cai los ntawm patent.
Lub femtosecond laser dynamic holographic ua txoj kev yog micro- thiab nanofabrication txheej txheem siv ultrashort pulsed lasers, uas yog tus cwj pwm los ntawm lub peev xwm ua tau zoo ntawm cov ntaub ntawv thiab kev tswj cov txheej txheem ntawm micro- thiab nanoscale. Cov thev naus laus zis no tshwj xeeb muaj txiaj ntsig zoo hauv kev tsim cov qauv microfabricated vim tias nws ua kom muaj kev txiav txim siab ntawm cov ntaub ntawv thiab kev hloov kho saum npoo ntawm micro- thiab nanoscale. Tshwj xeeb tshaj yog nyob rau hauv kev tsim kho ntawm peb-dimensional microfine lug, lub femtosecond laser dynamic holographic ua txoj kev yuav paub qhov zoo ua thiab ceev fabrication ntawm complex qauv, uas muab ib qho tseem ceeb kev txhawb nqa rau kev tsim kho ntawm microvascular tes hauj lwm.
Kev tsim kho ntawm peb-dimensional capillary network yog qhov tseem ceeb heev rau cov ntaub so ntswg engineering. Hauv kev npaj cov ntaub so ntswg thiab cov kabmob, cov ntshav zoo yog qhov tseem ceeb los xyuas kom muaj sia nyob ntawm tes thiab ua haujlwm. Txawm li cas los xij, ib txwm ua hauv vitro cov ntaub so ntswg engineering npaj feem ntau ua tsis tau zoo tsim lub vascular system, uas ua rau tsis muaj ntshav txaus tom qab kev cog qoob loo hauv vivo. Yog li ntawd, kev tsim kho ntawm peb-dimensional capillary tes hauj lwm nrog physiological functions yog ib qho tseem ceeb rau kev ua tiav kev loj hlob ruaj khov nyob rau lub sij hawm ntev thiab kev ua haujlwm ntawm cov ntaub so ntswg. Cov kev taw qhia ntawm femtosecond laser dynamic holographic ua txoj kev muab tshiab possibilities thiab technical support rau tsim microvascular tes hauj lwm. Los ntawm txoj kev no, kev tsim kho zoo ntawm microvascular scaffolds tuaj yeem ua tiav, muab cov kev daws teeb meem tshiab rau hauv vitro cov ntaub so ntswg engineering.
Rau kev tsim kho kom zoo ntawm 3D capillary scaffolds, femtosecond laser dynamic holographic processing method muaj qhov tshwj xeeb zoo. Ua ntej ntawm tag nrho cov, femtosecond laser dynamic holographic ua txoj kev tuaj yeem paub txog kev ua haujlwm siab thiab kev tswj hwm ntawm micro-scale, thiab nws cov kev ua tiav tuaj yeem ncav cuag submicron lossis txawm tias qib nanometer. Qhov no muab lub hauv paus tseem ceeb rau kev tsim cov microfine vascular scaffolds, uas tuaj yeem paub txog cov qauv tsim nyog thiab nyuaj. Thib ob, femtosecond laser dynamic holographic ua txoj kev yog tus cwj pwm los ntawm kev ceev ceev thiab kev ua haujlwm siab molding, uas tuaj yeem ua tiav qhov kev npaj ntawm cov txheej txheem microstructures nyob rau lub sijhawm luv luv, muab qhov ua tau ntawm kev npaj loj ntawm peb-seem capillary tes hauj lwm. . Yog li ntawd, daim ntawv thov ntawm femtosecond laser dynamic holographic ua txoj kev muaj ib qho tseem ceeb kev zoo nyob rau hauv kev tsim kho ntawm peb-dimensional capillary scaffolds.
Cov txiaj ntsig kev tshawb fawb cuam tshuam tau luam tawm hauvAdvanced Functional Materials, uas yog ib qho tseem ceeb nyob rau hauv lub tshav pob ntawm 3D capillary network tsim los ntawm femtosecond laser dynamic holographic ua txoj kev. Kev tshaj tawm ntawm cov txiaj ntsig no tsis yog tsuas yog ua pov thawj qhov ua tau thiab kev tsim kho tshiab ntawm cov thev naus laus zis no hauv kev tsim kho ntawm microvascular tes hauj lwm tab sis kuj tsim lub hauv paus rau kev tshawb fawb thiab kev siv hauv daim teb no. Los ntawm kev tshaj tawm hauv cov ntawv xov xwm kev kawm, cov txiaj ntsig kev tshawb fawb cuam tshuam yuav tau txais kev lees paub dav dav thiab kev saib xyuas, uas yuav pab txhawb kev siv thiab kev txhawb nqa ntawm cov thev naus laus zis no hauv kev tsim cov ntaub so ntswg.
Tsis tas li ntawd, cov cuab yeej muaj feem cuam tshuam tau raug tso cai los ntawm patent, uas txhais tau hais tias kev tshawb fawb tau ua tiav tseem ceeb hauv kev tsim kho thev naus laus zis thiab kev tiv thaiv kev txawj ntse. Kev tso cai patent tsis yog tsuas yog ib qho tseem ceeb rau cov neeg tshawb fawb tab sis tseem ceeb tshaj, nws tuaj yeem muab kev txhawb zog rau cov ntawv thov kev lag luam tom ntej thiab kev lag luam. Kev tiv thaiv cov cuab yeej kev txawj ntse ua kom muaj kev cai lij choj ntawm cov thev naus laus zis hauv kev sib tw ua lag luam, uas yog qhov tsim nyog rau kev nyiam cov nyiaj ntau thiab cov peev txheej los nqis peev hauv R & D thiab kev lag luam ntawm cov thev naus laus zis uas cuam tshuam, thiab txhawb kev hloov pauv ntawm kev tshawb fawb tshawb fawb hauv kev tsim khoom. .
Daim ntawv thov kev cia siab ntawm cov khoom siv hluav taws xob microvascular yog qhov dav heev. Ua ntej, cov thev naus laus zis no yog qhov tseem ceeb hauv kev ua haujlwm ntawm cov ntaub so ntswg engineering thiab cov tshuaj kho dua tshiab, uas tuaj yeem muab kev txhawb nqa lub cev tseem ceeb rau kev tsim cov khoom siv hauv nruab nrog cev thiab cov ntaub so ntswg, pab daws cov teeb meem ntawm cov hlab ntsha hauv cov hlab ntsha uas tau ntsib hauv cov ntaub so ntswg engineering, thiab muab cov ntaub so ntswg. tsim nyog tej yam kev mob rau lub sij hawm ntev kev ua haujlwm ruaj khov ntawm cov khoom nruab nrog cev. Qhov thib ob, kev tsim kho cov khoom siv hluav taws xob microvascular network kuj tseem muab cov cuab yeej tshawb fawb tshiab thiab lub platform rau kev tshuaj xyuas tshuaj, qauv kab mob, thiab lwm yam kev lag luam, uas pab txhawb kev tshawb fawb thiab kev siv cov txheej txheem hauv cov haujlwm muaj feem xyuam. Nyob rau hauv lub neej yav tom ntej, nrog rau kev txhim kho tas mus li thiab kev txhawb nqa ntawm cov khoom siv hluav taws xob microvascular network, nws ntseeg tau tias nws yuav qhia tau zoo rau kev siv peev xwm hauv ntau yam xws li tshuaj, bioengineering, thiab lwm yam, thiab coj cov kev cia siab tshiab thiab lub sijhawm rau tib neeg kev noj qab haus huv.
Los ntawm cov lus qhia saum toj no, nws yog ib qho yooj yim kom pom tias femtosecond laser dynamic holographic ua txoj kev muaj qhov tseem ceeb thiab dav daim ntawv thov kev cia siab nyob rau hauv lub teb ntawm dag microvascular network tsim. Nrog rau kev vam meej tas mus li thiab kev txhim kho ntawm cov thev naus laus zis muaj feem xyuam, peb ntseeg tias nws yuav ua rau muaj kev hloov pauv tseem ceeb thiab ua tiav hauv kev ua haujlwm ntawm cov ntaub so ntswg engineering thiab tshuaj kho dua tshiab, thiab ua kom muaj txiaj ntsig tseem ceeb rau kev noj qab haus huv ntawm tib neeg. Nyob rau hauv lub neej yav tom ntej, peb cia siab tias cov cuab yeej no yuav siv tau ntau dua thiab ua rau muaj kev xav tsis thoob thiab kev cia siab ntau ntxiv rau qhov ua rau tib neeg lub neej thiab kev noj qab haus huv.
